Abstract
Zieve syndrome is characterized by hepatic dysfunction, jaundice, hyperlipidaemia, and reversible hemolytic anaemia after alcohol abuse. We report a rare case of this syndrome presenting with coagulopathy and subcutaneous haemorrhage. Laboratory tests showed macrocytic anaemia, hyperbilirubinemia, increased activity of aminotransferases, hyperlipidemia, coagulopathy, signs of haemolysis: reduced concentration of haptoglobin, free hemoglobin. These abnormalities improved during 20 days. Ultrasonography revealed subcutaneous haemorrhagias, liver biopsy was consistent with steatohepatitis. There are a small number of reported cases of Zieve syndrome, and the reason could be the lack of pathognomonic symptoms, rapid decrease of hyperlipidaemic serum levels after alcohol withdrawal, patients denial of drinking. There is no specific treatment, therapy is similar to that for acute alcoholic hepatitis. The Zieve syndrome must be allways considered in the differential diagnosis of uncertain origin liver injury, hemolysis or coagulopathy.
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Jolanta Šumskienė,
Edita Šveikauskaitė,
Jūratė Kondrackienė,
Limas Kupčinskas,
Aorto-duodenal fistula: a rare but serious complication of gastrointestinal hemorrhage. A case report
,
Acta medica Lituanica: Vol. 23 No. 3 (2016)
-
Romanas Zykus,
Laimas Jonaitis,
Vitalija Petrenkienė,
Inga Gudinavičienė,
Limas Kupčinskas,
Combination of transient elastography with serum-based non-invasive tests improves prediction of liver fibrosis in patients with chronic hepatitis C: a prospective cohort study
,
Acta medica Lituanica: Vol. 22 No. 2 (2015)
-
Limas KUPČINSKAS,
Peter MALFERTHEINER,
Helicobacter pylori infection, premalignant gastric lesions and gastric cancer in the Baltic States: a review
,
Acta medica Lituanica: Vol. 18 No. 3 (2011)